Zoledronate activates NK cells.
نویسنده
چکیده
MSCs and osteoblastic but not endothelial and osteoclastic cells furthers our understanding of differential effects of individual niche components on specific HSC behaviors. Because the agrin receptor is present on human CD34 cells,9 this novel therapeutic target may be of use in clinical scenarios where specific expansion of ST-HSCs may reduce morbidity, such as in recovery from iatrogenic or toxic myeloablative injury. Conflict-of-interest disclosure: The author declares no competing financial interests. ■
منابع مشابه
Essential requirements of zoledronate-induced cytokine and γδ T cell proliferative responses.
The potent nitrogen-containing bisphosphonate zoledronate inhibits farnesyl pyrophosphate synthase, a key enzyme of the mevalonate pathway that is often hyperactive in malignant cells. Zoledronate activates human Vγ9Vδ2 T cells, which are immune sentinels of cell stress and tumors, through upstream accumulation of the cognate Ag isopentenyl pyrophosphate. IL-18 was shown to enhance zoledronate-...
متن کاملDC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes.
Bisphosphonates are mainly used for the inhibition of osteoclast-mediated bone resorption but also have been shown to induce γδ T-cell activation. Using IL-2-primed cultures of CD56(+) peripheral blood mononuclear cells, we show here that zoledronic acid (zoledronate) could induce IFN-γ production not only in γδ T lymphocytes but, surprisingly, also in natural killer (NK) cells in a manner that...
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The aim of this study is to establish osteoclasts as key immune effectors capable of activating the function of Natural Killer (NK) cells, and expanding their numbers, and to determine in vivo and in vitro effect of bisphosphonates (BPs) during NK cell interaction with osteoclasts and on systemic and local immune function. The profiles of 27 cytokines, chemokines and growth factors released fro...
متن کاملEssential Requirements of Zoledronate-Induced Cytokine and gd T Cell Proliferative Responses
The potent nitrogen-containing bisphosphonate zoledronate inhibits farnesyl pyrophosphate synthase, a key enzyme of the mevalonate pathway that is often hyperactive in malignant cells. Zoledronate activates human Vg9Vd2 T cells, which are immune sentinels of cell stress and tumors, through upstream accumulation of the cognate Ag isopentenyl pyrophosphate. IL-18 was shown to enhance zoledronate-...
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Natural Killer (NK) cells are innate immune lymphocytes specializing in recognition and killing of tumors and pathogens, using an array of activating and inhibitory receptors. NK inhibition is mediated by a large repertoire of inhibitory receptors, whereas a limited number of activating NK cell receptors execute NK cell activation. The ligands recognized by the activating receptors are stress-i...
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ورودعنوان ژورنال:
- Blood
دوره 118 10 شماره
صفحات -
تاریخ انتشار 2011